早期的暴露与性低矿化有关
Azza Tagelsir Ahmed1, Emily C Hector2, Jose Luis Urena-Cirett3
1Department of Pediatric Dentistry, College of Dentistry, University of Illinois Chicago, Chicago, Ill., USA, and is an adjunct researcher, Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Ind., USA.
Pediatric dentistry
|October 31, 2023
概括
产前暴露于,特别是在怀孕晚期,与墨西哥儿童的性低矿化 (MH) 有关. 这项研究强调了暴露在牙健康关键发育时期的风险.
科学领域:
- 环境健康 环境健康
- 儿科牙科 儿科牙科
- 毒理学 毒理学 毒理学
背景情况:
- 毛低矿化 (MH) 是一种严重的牙缺陷,影响牙质量.
- 产前和生命早期的环境暴露是MH的潜在风险因素.
- 了解暴露对儿童发育的影响至关重要.
研究的目的:
- 在墨西哥儿童中调查产前和早期生活中暴露和摩尔低矿化 (MH) 之间的关联.
- 量化与不同怀孕季度和幼儿时期的母亲血液中含量相关的MH风险.
主要方法:
- 来自墨西哥早期暴露于环境毒素 (ELEMENTS) 队列的506名儿童 (9-18岁) 的子组使用欧洲儿科牙科学会 (EAPD) 标准对MH进行了评估.
- 产前暴露通过母亲的骨 (骨,骨) 和血水平 (按季度和平均值) 进行测量.
- 产后暴露被通过分娩时的母亲血液和12个月和24个月的儿童血液来评估.
主要成果:
- 在接受检查的儿童中,有17.2% (87/506) 的儿童被诊断出毛低矿化 (MH).
- 在第三个三个月 (OR=1.08,95% CI=1.02-1.15) 和三个月的平均水平 (OR=1.10,95% CI=1.02-1.19) 中,母亲的血水平升高与MH有显著的关联.
- 在母亲的骨含量或儿童血液中的含量与MH存在之间没有发现显著的关联.
结论:
- 产前暴露,特别是在怀孕的第三个三个月,显著与增加的摩尔低矿性化风险有关.
- 这一发现强调了在关键的产前发育窗口期间尽量减少暴露的重要性.
- 进一步的研究可能会探索与晚期产前暴露与牙膜缺陷相关的具体机制.
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