异步的神经成熟预测过渡到精神病
Anton Iftimovici1,2,3, Julie Bourgin4, Josselin Houenou1,5
1NeuroSpin, CEA, Université Paris-Saclay, Gif-sur Yvette, France.
Psychiatry and clinical neurosciences
|October 31, 2023
概括
机器学习通过分析大脑结构成熟度,准确地预测精神病发作. 特定区域的异步大脑发育,如前额叶皮质,是这种预测特征的关键.
科学领域:
- 神经成像是一种神经成像.
- 机器学习 机器学习
- 精神病学是一个精神病学.
背景情况:
- 神经成像和机器学习用于根据大脑结构预测精神病发作.
- 解释这些与大脑结构相关的预测因素仍然是一个挑战.
- 了解大脑成熟对于识别精神病风险至关重要.
研究的目的:
- 开发一个可解释的机器学习模型来预测精神病发作.
- 为了确定特定的大脑区域及其成熟模式,预测精神病.
- 研究神经解剖学年龄在精神病预测中的作用.
主要方法:
- 在健康和处于危险精神状态 (UHR) 队列中使用基于声素的形态测量.
- 应用弹性网总变量 (Enet-TV) 通过交叉验证来预测精神病.
- 开发并验证了一个大脑年龄预测器,以评估区域成熟和大脑年龄差距.
主要成果:
- 在精神病预测方面取得了高绩效 (80%的AUC,69%的准确性).
- 确定了预测区域,包括腹中前额叶皮层 (体积增加) 和左前中心环/右轨道前额叶皮层 (体积减少).
- 观察到精神病转换预测区域的延迟成熟,以及其他地区的加速成熟.
结论:
- 可解释机器学习与大脑年龄建模相结合,揭示了异步成熟模式.
- 异步的区域间大脑成熟是精神病预测特征的关键组成部分.
- 这种方法增强了对精神病发展的神经生物学基础的理解.
相关概念视频
Cognitive Development During Adolescence
56
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
56
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
696
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
696
Psychological and Sociocultural Causes of Schizophrenia
92
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
92
Biological Causes of Schizophrenia
61
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
61
Schizophrenia
92
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
92
Autism Spectrum Disorder
104
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
104


