在COVID-19患者中,性别之间的热素值的差异
1Faculty of Medicine, Department of Cardiology, Biruni University, İstanbul, Turkey.
Medicine
|October 31, 2023
概括
在冠状病毒病 (COVID-19) 患者中,托罗邦水平因性别而异. 在男性中较低的热素升高表明心脏损伤,需要对不良事件进行临床警.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 冠状病毒疾病 (COVID-19) 可能导致严重的心脏并发症.
- 热波水平是心脏损伤的关键指标.
- 越来越多地认识到COVID-19结果和心脏参与的基于性别的差异.
研究的目的:
- 为了调查吸收热宁值的性别特异性差异.
- 分析热素水平与医院结局之间的关联.
- 评估COVID-19患者的两年随访结果与性别和热素水平相关的结果.
主要方法:
- 对826名中度至重度COVID-19患者 (438名女性,388名男性) 的回顾性分析.
- 记录的临床事件 (ICU入院,呼吸衰竭,心脏损伤,死亡率) 和2年累积终点 (所有原因死亡率,再住院,中风).
- 研究了热波宁值,临床事件和累积终点的性别差异,并确定了不良结果的风险因素.
主要成果:
- 女性患者的平均年龄和并发病率较高. 呼吸衰竭在男性中更为频繁.
- 住院生存率在性别之间有显著差异 (女性:16天,男性:14天).
- 在2年的随访期间,男性的累积终点较高. 心脏损伤与女性的氨酸≥93 pg/mL和男性的氨酸≥28 pg/mL有关,男性的氨酸水平较低表明受伤.
结论:
- 热素值及其与心脏损伤和临床事件的关联在COVID-19患者的性别之间存在显著差异.
- 在男性中,较低的平素升高表明心脏损伤,并预测不良临床事件.
- 临床医生应了解在COVID-19管理中检测心脏损伤的性别特异性热素值.
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