发生在骨和关节的肉瘤的预后因素:基于SEER的研究
Hongfei Zhou1,2, Shaohui He1, Dan Zhang1
1Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Medicine
|October 31, 2023
概括
这项研究分析了2008年至2014年的骨和关节肉瘤,确定了关键的预后因素,如年龄,瘤部位和等级. 开发了一个名图表,以改善肉瘤患者的生存预测.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 骨和关节的肉瘤是一种罕见但具有攻击性的恶性瘤.
- 了解他们的流行病学,治疗和预后对于患者的治疗结果至关重要.
研究的目的:
- 为了澄清骨和关节肉瘤的流行病学,治疗和预后.
- 在这些患者中开发整体存活 (OS) 的预测模型.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 18个注册 (2008-2014).
- 包括2794名患有显微镜确认的骨关节肉瘤的患者.
- 采用了卡普兰-梅尔分析,后勤回归,考克斯比例危险模型和名ograms.
主要成果:
- 确定了与瘤转移相关的八个因素 (年龄,种族,性别,瘤部位,组织学,等级,大小,TNOMT).
- 对OS确定了9个独立的预后因素,包括年龄,性别,瘤部位,组织学,等级,大小,程度,手术和TNOMT.
- 一个名图显示了预测和观察到的生存时间之间很好的一致性 (C指数 = 0.814).
- 化疗改善了Ewing瘤和不分化的瘤的生存率;放射治疗没有显著的OS益处.
结论:
- 建立了基于人口的骨肉瘤预后估计.
- 诺莫图提供了一个更准确的预后预测工具,用于骨和关节肉瘤.
- 化疗和手术等治疗因素显著影响OS,而放射治疗的作用需要进一步调查.
相关概念视频
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:21Cancer Survival Analysis
357
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
357
01:03Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K