过敏性鼻炎中的鼻子微生物 儿童 具有或没有语言下免疫疗法
Xiao-Fei Shen1, Zhi-Pan Teng1, Qi Li1
1Department of Otorhinolaryngology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
过敏性鼻炎 (AR) 患者表现出明显的鼻腔微生物群多样性和细菌组成. 舌下免疫疗法 (SLIT) 治疗有助于恢复鼻腔微生物群接近健康水平.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
背景情况:
- 过敏性鼻炎 (AR) 的发病包括环境和遗传因素,鼻腔是主要的过敏原接触点.
- 语言下免疫疗法 (SLIT) 通过免疫调节修改AR的过程,提供持续的疗效.
- 鼻子微生物组在AR发展和治疗反应中的作用在很大程度上仍未被探索.
研究的目的:
- 为了研究过敏性鼻炎 (AR) 患者的鼻腔微生物组合.
- 为了分析下语言免疫疗法 (SLIT) 后鼻子微生物组的变化.
- 为了比较AR患者的鼻子微生物组,SLIT治疗患者和健康对照组.
主要方法:
- 横截面研究设计. 截面研究设计.
- 从三个组采集鼻子拭子:AR患者 (从未接受过SLIT),AR患者经历长期SLIT (>2年) 和对照组 (CG).
- 16S rDNA测序用于全面的鼻子微生物组分析.
主要成果:
- 与CG和SLIT组相比,AR组表现出明显更高的鼻腔微生物群多样性 (辛普森指数).
- 在AR群中,Bacteroidetes和Firmicutes类特别丰富.
- SLIT 治疗导致 Bacteroidetes 丰度的减少,使其更接近 CG 水平.
结论:
- 肺炎患者具有独特的鼻腔微生物组合.
- 治疗SLIT似乎调节了鼻子微生物群,可能恢复到更健康的状态.
- 需要进一步的研究来阐明鼻腔微生物组合和AR发展或进展之间的因果关系.
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