瓦尔甘西克洛维尔调节瘤亡因子轴分子表达和CD4+T细胞子集在扩散卡波西肉瘤患者中的表达
Lucero A Ramon-Luing1, Julio Flores-Gonzalez1, Luis Angel García-Rojas1
1Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
Clinical and experimental immunology
|October 31, 2023
概括
瓦尔甘西克洛维尔 (VGC) 补充疗法在扩散卡波西肉瘤/艾滋病毒患者中调节T细胞激活和瘤亡因子 (TNF) /TNFRs轴,改善炎症状态调节.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 散布的卡波西肉瘤/艾滋病毒 (DKS/HIV) 患者表现出失调的T细胞反应和炎症.
- 瘤亡因子 (TNF) 和其受体 (TNFRs) 轴在T细胞激活和免疫调节中发挥着关键作用.
研究的目的:
- 评估瓦尔甘西克洛维尔 (VGC) 作为辅助治疗对DKS/HIV患者T细胞子集和TNF/TNFRs轴的影响.
- 为了比较一个实验性疗法 (ER) 与常规治疗 (CT) 关于免疫调节.
主要方法:
- 随机临床试验涉及接受ER (VGC + cART) 或CT (cART) 的DKS/HIV患者.
- 在基线,4周和12周对单核细胞的分析,以评估T细胞子集和TNF/TNFRs表达.
- 对T细胞子集,HHV-8病毒载量和TNF/TNFRs水平之间的相关性分析.
主要成果:
- DKS/HIV患者的CD8+T细胞增加,CD8表达高.
- ER增加了原始和中央记忆中的CD4+T细胞和平衡的激活的CD4+T细胞子集.
- ER降低了可溶性TNFR2,而CT降低了跨膜TNF形式. ER与TNF/TNFRs水平呈正相关性.
结论:
- 瓦尔甘西克洛维尔补充疗法在DKS/HIV患者中逐渐调节CD4+T细胞激活和TNF/TNFRs轴.
- VGC治疗表明,在DKS/HIV患者中改善了炎症状态的调节.
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