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Updated: Jul 12, 2025

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2011-2019年荷兰早产的趋势:2011-2019年荷兰早产的趋势:2011-2019年荷兰早产的趋势:2011-2019年荷兰早产的趋势:2011-2019年荷兰早产的趋势:2011-2019年荷兰早产的趋势:2012-2019
Job Klumper1,2, Anita C J Ravelli1,2,3, Carolien Roos1,2
1Department of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Acta obstetricia et gynecologica Scandinavica
|October 31, 2023
概括
2011-2019年,荷兰的早产率有所下降,主要是由于较少的催产素和晚期早产. 然而,自发的极端和非常早产增加,突出了需要关注的特定子组.
科学领域:
- 产科和妇科 产科和妇科
- 围产期流行病学 围产期流行病学
- 公共卫生 公共卫生
背景情况:
- 过早出生 (PTB) 仍然是导致婴儿死亡和发病的全球主要原因.
- 荷兰已经观察到PTB率的下降,这可能与实施的预防策略有关.
- 了解特定子组的趋势对于有针对性的未来干预至关重要.
研究的目的:
- 评估2011年至2019年期间荷兰早产率 (PTB) 的整体趋势.
- 分析PTB趋势在特定的临床亚型 (自发与阴性) 和妊娠年龄亚组.
- 为了确定需要专注关注未来PTB预防策略的子组.
主要方法:
- 分析2011-2019年单胎和多胎妊娠国家围产阶段登记数据.
- 在五个妊娠年龄类别和两个临床亚型中评估PTB率.
- 使用Cochran Armitage测试进行趋势分析,并比较早期和晚期的研究期.
主要成果:
- 单身患者的整体PTB比率显著下降 (5.5%至5.0%),主要是由于阴性PTBs的减少.
- 观察到中度到晚期自发PTB的减少,但自发极端和非常PTB的显着增加.
- 在多胎妊娠中,PTB的发病率保持稳定 (52.3%至54.1%).
- 在25岁以上的女性,无双/初双女性,中高社会经济地位的女性和高血压女性中观察到PTB的下降.
结论:
- 2011年至2019年期间,荷兰的早产率下降,主要是由于晚期和阳性产生的PTBs的减少.
- 自发的极端和非常早产显示出日益增长的趋势,需要进一步调查.
- 未来的预防工作应优先考虑没有下降的PTB率的子组,包括年轻女性和社会经济地位较低的女性.
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