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在脑膜炎患者中脑脊髓液的蛋白质组与重新激活的疹病毒 (varicella zoster virus) 的脑膜炎患者

Huili Liu¹, Jun Wang¹, Yan Zhang¹

¹Department of Neurology, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Immunity, inflammation and disease

|October 31, 2023

概括

疹病毒 (VZV) 脑膜炎涉及显著的炎症和免疫细胞激活,与神经功能蛋白减少. 大脑脊髓液 (CSF) 的IL-18水平可以预测患者的结果.

科学领域:

神经病毒学神经病毒学
蛋白质组学是指蛋白质组学.
免疫学免疫学免疫学

背景情况:

疹病毒 (VZV) 的重新激活可能导致中枢神经系统 (CNS) 感染,例如VZV脑膜炎.
了解大脑脊髓液 (CSF) 中的蛋白质变化对于阐明VZV诱导的中枢神经系统疾病的致病性至关重要.

研究的目的:

为了研究VZV脑膜炎患者的CSF蛋白质特征.
为了确定VZV脑膜炎患者之间脑液蛋白质组的差异,具有有利和不利的结果.
为了比较VZV脑膜炎和疹 (HZ) 患者之间的CSF蛋白质特征.

主要方法:

使用数据独立采集模型对CSF样本进行蛋白质组分析.
28名VZV脑膜炎患者和11名HZ患者的CSF蛋白质组数据的比较.
将VZV脑膜炎患者分为有利和不利的结局组,根据临床表现进行比较蛋白质组分析.

主要成果:

与炎症和免疫细胞激活相关的蛋白质 (例如,CXCL10,ELANE,IL-1RN,MPO,PRTN3) 与HZ患者相比,在VZV脑膜炎患者中显著上调 (p < .01).
参与神经功能和能量代谢的蛋白质 (例如CKMT1B,SLITRK3,Synaptotagmin-3,KIF5B) 在VZV脑膜炎患者中显著下调 (p < .05).
在VZV脑膜炎患者中,与预后良好 (p < .05) 患者相比,在VZV脑膜炎患者中观察到脑脊液中益炎因子IL-18的水平升高.

结论:

炎症和免疫反应是VZV诱导的中枢神经系统感染的关键病理生理机制.
大脑脊髓液IL-18水平显示出作为VZV脑膜炎结果的预后生物标志物的潜力.

关键词:

大脑脊髓液中的脑脊液.脑膜炎是一种脑膜炎.蛋白质组学蛋白质组学疹病毒-疹病毒病毒.

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