血交换在怀孕期间系统性红斑狼的临床疗效

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Fen Zhang¹, Bing-Ying Zhang², Ru Fan¹

¹Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, China.

Immunity, inflammation and disease

|October 31, 2023

概括

血交换 (PE) 与普雷尼松和化 (HCQ) 结合,与单独的HCQ和普雷尼松相比,改善了全身性红斑狼 (SLE) 的妇女的妊娠结果和产后状况.

科学领域:

产科和妇科产科和妇科
类风湿病学类风湿病学
免疫学免疫学免疫学

背景情况:

在怀孕期间,全身性红斑狼 (SLE) 对母亲和胎儿都有重大风险.
怀孕期间活跃SLE的最佳管理策略对于改善结果至关重要.

研究的目的:

评估血交换 (PE) 与普得尼松和化 (HCQ) 结合治疗孕妇患有SLE的临床疗效.
为了比较孕妇SLE患者接受PE加标准治疗和单独标准治疗之间的结果.

主要方法:

对14名患有SLE的孕妇进行了回顾性分析.
患者被分为两个组:非PE (仅用于普雷尼松和HCQ) 和PE (用于普雷尼松,HCQ和PE).
对比了临床特征,分娩结果和产后疾病标志物 (ESR,尿蛋白,血小板计数,SLEDAI).

主要成果:

所有PE组的患者均分娩成功,而非PE组的3名患者则流产.
在产后6个月和12个月,PE组的红细胞沉率 (ESR) 显著降低.
与非PE组相比,PE组显示出产后疾病活性降低 (SLEDAI得分) 和血小板计数改善.

结论:

与PE,普得尼松和HCQ的联合治疗似乎比单独的普得尼松和HCQ更有效,用于怀孕期间活跃的SLE.
这种综合方法可以减少怀孕流产,并改善母亲的产后状况.

关键词:

有效性有效性有效性.血相结合酶 (Plasmapheresis) 是一种怀孕怀孕怀孕怀孕怀孕系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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