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Updated: Jul 12, 2025

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome

Published on: March 24, 2023

使用两步丰富蛋白质组学来定义细胞表面囊蛋白.

Tianyang Yan^1,2, Lisa M Boatner^1,2, Liujuan Cui^1,3

¹Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA).

bioRxiv : the preprint server for biology

|October 31, 2023

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一种名为Cys-Surf的新方法通过捕获更多的膜蛋白囊蛋白来增强细胞表面蛋白质组分析. 这种方法揭示了新的可结合和氧化还原敏感部位,释放了治疗潜力.

科学领域:

蛋白质组学是指蛋白质组学.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

血膜蛋白质组提供了有价值的治疗点,但由于蛋白质的特征,其研究具有挑战性.
现有的蛋白质组方法在细胞表面蛋白质组的样本下,限制了发现.

结论:

该Cys-Surf平台提供了一个量身定制的方法来探索等离子体膜cysteinome.
这种方法增强了对细胞表面蛋白的功能和治疗潜力的理解.

关键词:

细胞表面细胞表面化学蛋白质组学化学蛋白质组学化学蛋白质组学半氨酸 (cysteines) 是一种氨酸.氧化状态氧化状态在T细胞激活过程中,

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