在巨细胞中,雄激素阻断原体NLRP3诱导瘤细胞分裂
bioRxiv : the preprint server for biology
|October 31, 2023
概括
新的研究表明,向瘤相关巨细胞 (TAMs) 中的NLRP3炎症酶可以克服转移性割抗性前列腺癌 (mCRPC) 中的免疫抑制,从而显著控制瘤.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 免疫疗法在转移性割抗性前列腺癌 (mCRPC) 中显示出有限的疗效,原因是瘤免疫微环境 (TME) 中的免疫抑制性瘤相关巨细胞 (TAM).
- 需要治疗策略来克服mCRPC中TAM介导的免疫抑制.
结论:
- 在mCRPC中,NLRP3充当了AR调节的"巨菌细胞检查点".
- ADT会诱导TAM中的NLRP3表达,而NLRP3a的激活会增强TAM介导的细胞分裂.
- ADT和NLRP3a的组合促进了TAM介导的细胞分裂,导致晚期前列腺癌的瘤控制.
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