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Updated: Jul 12, 2025

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

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与帕金森病相关的LRRK2-G2019S破坏了AMPAR贩运,细胞类型和亚单元特异性的纹状体中的移动性和组成

Swati Gupta, Christopher A Guevara, Alexander Tielemans

    bioRxiv : the preprint server for biology
    |October 31, 2023
    PubMed
    概括

    帕金森病 (PD) 涉及与LRRK2突变相关的认知缺陷. 这项研究揭示了AMPA受体在特定脑细胞中的异常贩运,影响突触功能并导致PD相关的认知障碍.

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    Assaying the Kinase Activity of LRRK2 in vitro

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