抑制ERK1/2可以缓解噪音引起的听力损失,同时缓解免疫反应
Richard D Lutze1, Matthew A Ingersoll1, Alena Thotam1
1Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.
bioRxiv : the preprint server for biology
|October 31, 2023
概括
一种ERK1/2抑制剂Tizaterkib显著保护小鼠免受噪音引起的听力损失. 这种药物通过向MAPK通路,有望预防听力损伤.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 噪音引起的听力损失 (NIHL) 是听力损失的普遍原因,目前没有FDA批准的预防药物.
- 线素激活蛋白激酶 (MAPK) 途径是缓解NIHL的潜在治疗标.
结论:
- 在小鼠中,Tizaterkib有效地预防NIHL和相关的耳突触.
- 药物的保护机制涉及MAPK通路和调节耳免疫反应.
- 提扎特基布具有广泛的治疗窗口 (>50) 并需要进一步研究用于保护听力的人类临床应用.
相关概念视频
01:28Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
01:24T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K