上半圆通道消声和随后的关闭导致可逆的决策受损
Todd M Mowery1,2, P Ashley Wackym1,2, Jacqueline Nacipucha1
1Department of Otolaryngology - Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Frontiers in neurology
|October 31, 2023
概括
静脉管功能障碍,如上半圆通道听力障碍 (SSCD),会影响决策和认知功能. 这项对鼠的研究证实,前体不对称导致认知缺陷,突出了中枢神经系统的参与.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 认知科学 认知科学
背景情况:
- 垂体损失与认知缺陷有关,包括空间导航,记忆和执行功能.
- 上半圆通道听力衰竭 (SSCD) 是一种前体障碍,导致头和听力丧失等症状,也会导致认知障碍.
- 中枢神经系统机制被怀疑是前庭功能障碍相关的认知缺陷.
研究的目的:
- 为了研究前体障碍会损害认知功能的假设.
- 在gerbil模型中直接测试SSCD对听觉和视觉决策任务的影响.
主要方法:
- 成年大鼠 (n=33) 接受了不同难度的听觉和视觉Go-NoGo区分任务的训练.
- 对上半圆通道进行了外科窗,以模拟SSCD.
- 行为表现 (d-primes) 和前庭引起的肌原潜力 (VEMPs) 在手术前和后被评估.
主要成果:
- 在决策任务中,SSCD显著改变了行为表现 (d-prime).
- 认知缺陷与持续的前庭功能障碍 (c+VEMPs) 有关.
- 对照小鼠显示学习后过程,而SSCD组没有.
结论:
- 异常,不对称的前庭输出导致决策障碍.
- 这些发现支持前庭功能障碍与更广泛的认知缺陷之间的联系.
- 中央机制参与了与前体障碍相关的认知障碍.
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