肥胖的临床分类和对代谢功能障碍相关的脂肪肝疾病和治疗的影响
Yuping Ding1,2, Quanjun Deng1,2, Mei Yang1,2
1Department of Gastroenterology and Hepatology, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, 300162, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|October 31, 2023
概括
肥胖和与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是全球流行病. 针对肥胖和MAFLD的治疗可以降低患2型糖尿病 (T2DM) 的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 肥胖和与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 在全球普遍存在,经常存在并增加肝脏和肝外并发症的风险.
- 2型糖尿病 (T2DM) 显著加快了MAFLD的进展,而晚期MAFLD则增加了T2DM发病率风险.
- 诊断MAFLD的标准包括肝脏肥胖症加上超重/肥胖,T2DM或正常体重个体的代谢失调.
研究的目的:
- 审查肥胖和MAFLD的临床分类和相互关系.
- 突出内脏肥胖和胰岛素抵抗 (IR) 在MAFLD病变发生中的作用.
- 总结目前减轻T2DM风险的肥胖和MAFLD治疗方法.
主要方法:
- 文献综述侧重于临床分类和肥胖和MAFLD之间的相关性.
- 对肥胖和MAFLD对临床结果的协同影响的分析.
- 关于预防T2DM的肥胖和MAFLD治疗策略的摘要.
主要成果:
- 肥胖和MAFLD之间的关系是复杂的,超出了简单的分类.
- 内脏肥胖和IR是MAFLD发展的关键驱动因素.
- 肥胖和MAFLD的治疗显示出降低T2DM发病率的潜力.
结论:
- 肥胖和MAFLD代表着一个重要的全球健康挑战,具有相互关联的风险.
- 通过生活方式和药物干预措施准肥胖和MAFLD可以预防T2DM.
- 对基于肝脏的治疗方法的进一步研究可能为T2DM预防提供新的策略.
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