基于酒精消费水平的癌症风险:一个全面的系统审查和元分析
Seunghee Jun1,2, Hyunjin Park1,2, Ui-Jeong Kim1
1Department of Preventive Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Epidemiology and health
|October 31, 2023
概括
即使是轻度饮酒也会增加癌症风险,没有确定安全水平. 这次系统性审查和元分析发现了各种癌症的剂量反应关系,强调了减少酒精的公共卫生干预措施.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 酒精消费是已知的致癌物质,但轻度饮酒对癌症风险的影响仍在争论中.
- 之前的研究已经广泛探索了酒精与癌症的联系,但对低水平的饮酒缺乏明确的结论.
研究的目的:
- 进行系统性审查和元分析,调查不同程度的酒精消费与多种癌症风险之间的联系.
- 为了澄清轻度饮酒对整体和特定癌症风险的影响.
主要方法:
- 系统审查和对来自139个队列研究的前性数据的元分析.
- 从106项包括研究的数据进行了定量综合,以评估酒精消费水平和癌症风险.
主要成果:
- 轻度饮酒与全因癌症风险之间没有发现显著的关联 (RR,1.02;95% CI,0.99-1.04).
- 观察到剂量反应关系:轻度饮酒增加了食道,结肠直肠和乳腺癌的风险.
- 轻度至中度饮酒增加了食道,结肠直肠,喉和乳腺癌的风险;大量饮酒与胃,肝脏,胰腺和前列腺癌有关.
结论:
- 癌症风险与所有水平的酒精消费有关,包括轻度消费.
- 关于癌症风险的饮酒没有确定的安全门.
- 公共卫生战略应解决饮酒问题,以减少癌症发病率.
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