治疗-预后-调整一种新的治疗理念,通过分析瘤微环境中的T细胞免疫检查点,通过算法:一个图书法分析分析
Shiwei Ma1, Xin Wu2, Zhongguang Wu3
1Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China.
Human vaccines & immunotherapeutics
|October 31, 2023
概括
这项研究绘制了瘤微环境的知识网络,并预测了研究的预后. 关键趋势显示,人们正在转向预后预测和非瘤细胞,指导未来的癌症研究.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
背景情况:
- 瘤微环境 (TME) 显著影响癌症的进展和患者的结果.
- 了解TME在预后中的作用对于开发有效的癌症疗法至关重要.
研究的目的:
- 分析瘤微环境和预后研究的时间和空间分布.
- 确定新兴的研究热点和该领域的未来趋势.
主要方法:
- 在科学网络数据库中对1999年至2022年的文章和评论进行了文献计量分析.
- 利用CiteSpace和VOSviewer进行知识网络可视化,分析期刊,机构,国家,作者和关键词.
- 微软Excel 2019用于全面的视觉分析.
主要成果:
- 免疫学的边界,癌症和瘤学的边界是领先的期刊. 中国和美国的出版物占据主导地位,富丹大学和孙中山大学是关键机构.
- 研究重点已经从瘤细胞行为和相关分子演变为预后预测,生存分析,免疫细胞透和预测模型.
- 关键的研究领域包括微环境,预后和免疫疗法,显著转向非瘤细胞和预测应用.
结论:
- 瘤微环境和预后的研究格局是动态的,有一个明确的趋势是预测建模和理解非瘤组件.
- 未来的研究应该专注于利用TME变化来预测预后,并指导个性化癌症治疗策略.
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