在患有双相情感障碍的年轻人中,冠状动脉微血管反应功能受损
Kody G Kennedy1,2, Nilesh R Ghugre3,4, Idan Roifman3
1Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Psychological medicine
|October 31, 2023
概括
患有双相情感障碍 (BD) 的年轻人表现出冠状动脉微血管功能受损,这是心血管疾病风险的关键指标. 这种早期功能障碍即使在年轻人心脏结构和功能正常的情况下也会发生.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 双极性障碍 (BD) 与早发性心血管疾病 (CVD) 的高发率有关.
- 微血管功能障碍可能解释BD患者心血管疾病风险增加.
- 这项研究调查了患有BD的年轻人的冠状动脉微血管功能.
研究的目的:
- 在患有BD的青少年和年轻成年人中评估冠状动脉微血管活性 (CMVR).
- 为了比较患有BD的年轻人与健康对照者之间的CMVR.
- 为了确定若年BD患者是否存在微血管功能障碍.
主要方法:
- 定量T2磁共振成像 (MRI) 用于在86名参与者 (39名与BD,47名对照) 的呼吸挑战期间评估CMVR.
- 使用心脏门的影像来评估左心室的结构和功能.
- 线性混合效应模型对年龄,性别和BMI进行控制,以便在不同组之间比较CMVR.
主要成果:
- 与对照人群相比,在患有BD的年轻人中,CMVR显著较低.
- 较低的T2放松时间,表明微血管功能受损,在BD年轻人中观察到喘息期间.
- 两组之间没有发现严重的左心室结构或功能的显著差异.
结论:
- 患有BD的青少年和年轻人表现出亚临床性冠状动脉微血管功能受损.
- 这一发现表明早期的血管异常有助于BD中心血管疾病风险.
- 建议使用更大的样本和纵向数据进行进一步的研究.
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