探索1岁后代的围产期生物心理社会因素和表观遗传年龄
Peter D Fransquet1, Jacqui A Macdonald1,2,3, Joanne Ryan4
1Deakin University, Centre for Social & Early Emotional Development, School of Psychology, Faculty of Health, Geelong, Victoria, Australia.
Epigenomics
|October 31, 2023
概括
孕妇的心理健康,压力和怀孕期间的身体健康都会影响婴儿的表观遗传衰老. 焦虑,BMI和关系质量等因素与儿科表观遗传钟的差异有关.
科学领域:
- 儿科表观遗传学 儿科表观遗传学
- 健康和疾病的发育起源.
背景情况:
- 儿童表观遗传衰老的决定因素尚不清楚.
- 早期生活因素可能会显著影响长期健康轨迹.
研究的目的:
- 调查与婴儿表观遗传衰老相关的母性因素.
- 探索孕产妇健康指标与儿科表观遗传钟之间的联系.
主要方法:
- 在258名1岁儿童的表观遗传年龄估计中,使用了儿科口腔和Horvath钟.
- 评估母亲的心理健康,关系健康,物质使用和身体健康在第三个三个月.
主要成果:
- 母亲的焦虑,压力,BMI和关系质量与儿科口腔表观遗传时钟差异相关.
- 怀孕期间的高血压与Horvath年龄加速有关.
- 第三个三个月的吸烟和怀孕前的体重分别在两个时钟中呈现加速和减速.
结论:
- 怀孕期间多个母亲因素可能会影响婴儿的表观遗传年龄.
- 需要进一步的研究来了解这些发现对健康和发育的影响.
关键词:
通过DNA甲基化.霍尔瓦特 (Horvath) 是一个古老的城市.在PedBE中使用PedBE.老化的老化 衰老的老化表观遗传时钟的时间表.心理健康 心理健康儿科 儿科 儿科 儿科周产阶段 周产阶段使用物质使用物质.更多相关视频
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