数据驱动的MRI分析显示,在运动干预后,默认模式网络和认知中与健身相关的功能变化
Katherine M Lloyd1, Timothy P Morris1, Sheeba Anteraper2
1Northeastern University, Boston, Massachusetts, USA.
Psychophysiology
|October 31, 2023
概括
在老年人中,更高的心肺呼吸能力 (CRF) 与运动期间改善的大脑连接变化有关. 这些连接性改善与更好的认知功能相关,特别是感知速度,经过6个月的干预.
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 老年学是指老年学的学科.
背景情况:
- 心血管健康 (CRF) 在老年人中显示出神经保护作用.
- 将CRF与认知和大脑健康联系在一起的精确机制需要进一步研究.
研究的目的:
- 为了检查前干预CRF和运动干预期间功能性大脑连接的变化之间的关联.
- 为了确定改变的大脑连接是否与干预后改善的认知表现有关.
主要方法:
- 对139名低活动的老年人进行了为期6个月的运动干预.
- 休息状态fMRI和神经心理测试评估了干预前后的大脑连接和认知功能.
- 数据驱动的多声元模式分析发现了全脑连接模式的变化.
主要成果:
- 较高的干预前CRF与前中枢环内功能连接的更大变化相关.
- 与CRF相关的连接变化涉及背部注意网络 (DAN) 的网络内相关性增加和默认模式网络 (DMN) 的反相关性.
- 前中心环和DMN集群之间的连接变化与增强的感知速度性能有关.
结论:
- 即使是CRF中适度的差异也可以影响功能性大脑连接的变化以及运动后老年人与认知的关系.
- 研究结果强调了CRF在调节大脑网络动态和对身体活动的反应认知结果中的作用.
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