在瑞士儿童癌症幸存者的肺功能纵向评估-多中心队列研究
Rahel Kasteler1,2,3, Maria Otth1,2,3, Florian S Halbeisen4
1Childhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Pediatric pulmonology
|October 31, 2023
概括
儿童癌症幸存者经常经历由于治疗而减少的肺功能. 纵向研究表明持续的低肺功能,特别是在胸部手术后,突出需要持续监测.
科学领域:
- 儿科瘤学 儿科瘤学
- 肺部病理学 肺部病理学
- 癌症的生存率 癌症的生存率
背景情况:
- 儿童癌症幸存者面临着化学疗法,辐射和手术等治疗的肺损伤风险.
- 这些幸存者的肺功能变化的纵向数据有限.
研究的目的:
- 随着时间的推移,检查儿童癌症幸存者的肺功能轨迹.
- 为了确定肺功能下降和特定的肺毒性治疗之间的关联.
主要方法:
- 对1990-2013年诊断的瑞士幸存者的回顾性多中心队列研究.
- 分析肺功能测试 (PFTs),包括FEV1和FVC,计算z分数和预测的百分比.
- 多变量线性回归用于确定FEV1和FVC变化的风险因素.
主要成果:
- 183名幸存者与790名PFT;中位数随访时间为5.5年.
- 49%的人有异常的PFT,主要是限制性模式 (22%).
- 在整个随访期间,肺功能 (FEV1,FVC) 仍然很低,从-1.5 z-score开始. 胸腔手术与显著降低FEV1和FVCz-score相关.
结论:
- 儿童癌症幸存者的肺功能下降是常见的,通常是轻度至中度的.
- 长期监测和进一步的研究对于这个脆弱的人群至关重要.
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