[年龄和幼儿园儿童中Streptococcus pneumoniae疫苗接种覆盖率之间的剂量反应关系]
Ting Li1, Wen-Jun Deng1, Jing-Feng Zhang1
1Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.
年龄对幼儿园儿童的肺炎菌杆菌疫苗接种覆盖率产生重大影响,2岁儿童的PCV10和PCV13疫苗接种率最高. 病毒性基因lytA和ply是新蛋白质疫苗的有希望的候选者.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗学 疫苗学 疫苗学
- 微生物学 微生物学
背景情况:
- 肺炎性 estreptococcus 是导致严重的儿童疾病.
- 肺炎球菌联合疫苗 (PCV) 对于预防至关重要.
- 了解与年龄相关的疫苗接种覆盖率是公共卫生战略的关键.
研究的目的:
- 为了检查儿童年龄和Streptococcus pneumoniae疫苗接种覆盖率之间的关系.
- 为疫苗接种策略和新型蛋白质疫苗的开发提供信息.
主要方法:
- 在1,830名幼儿园儿童中进行了分层集群随机抽样.
- 鼻口腔抹布用于Streptococcus pneumoniae的隔离和识别.
- 使用受限立方线的物流回归来分析年龄和覆盖范围的关系.
主要成果:
- 22.46%的儿童携带了肺炎链球菌;主要的血清型被确定.
- PCV10和PCV13的覆盖率分别为53.0%和57.9%.
- 显著的非线性PCV10/PCV13与年龄相关的覆盖率,在2岁达到峰值 (88.0%/91.1%).
- 针对PI-1 (37.7%) 和PI-2 (16.1%) 疫苗的覆盖率较低.
- 对lytA (99.5%) 和ply (99.0%) 基因的高覆盖率表明了蛋白质疫苗的潜力.
结论:
- 在幼儿园儿童中,年龄和PCV10/PCV13覆盖率之间存在显著的非线性关系.
- 2岁的孩子表现出最高的PCV覆盖率.
- lysta和ply的高患病率表明它们有可能成为下一代重组蛋白质疫苗的目标.
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