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MIR938 rs2505901 T>C多态性与中国儿童神经母细胞瘤风险增加有关

Susu Jiang^1,2, Xiuhong Sun³, Xinxin Zhang²

¹Department of Child and Adolescent Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province 510006, China.

Bioscience reports

|October 31, 2023

概括

在中国儿童中,MIR938 (rs2505901 T>C) 的特定遗传变异与儿童神经母细胞瘤 (NB) 的风险增加有关. 需要对不同种群进行进一步的研究来证实这一关联.

科学领域:

遗传学是一个遗传学.
儿科瘤学儿科瘤学
分子生物学分子生物学

背景情况:

神经母细胞瘤 (NB) 是一个重要的儿童癌症.
MIR938基因微RNA在基因表达调制中发挥作用.
之前的研究表明,MIR938可能与各种癌症有关.

研究的目的:

调查MIR938遗传变异与神经母细胞瘤风险之间的关联.
分析MIR938 rs2505901 T>C单核酸多态 (SNP) 对NB易感性的影响.

主要方法:

一项病例控制研究与402名神经母细胞瘤患者和473名对照进行.
进行了MIR938 rs2505901 T>C SNP的基因定型.
统计分析,包括赔率比率 (OR) 和置信区间 (CI),用于评估风险.

主要成果:

MIR938 rs2505901 T>C多态性与神经母细胞瘤的风险增加显著相关.
与TT相比,具有CC基因型的个体具有更高的NB风险 (OR=1.90,P=0.045) .
在较小的儿童 (≤18个月),男性和高级阶段 (III+IV) 观察到边界显著的关联.

结论:

MIR938 rs2505901 T>C多态可能是中国儿童神经母细胞瘤的潜在危险因素.
为了验证MIR938多形态在NB发展中的作用,需要进行更大规模的多民族研究.

关键词:

在MIR93838中,您可以使用MIR.神经母细胞瘤的神经母细胞瘤多形态主义的多态主义.易感性易感性易感性

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