血清尿酸与肌素的比率作为持续门诊腹腔透析患者死亡的风险因素:一项多中心回顾性研究
Jieping Hu1,2, Liwen Tang2, Xiaojiang Zhan3
1Department of Nephrology, Dongguan Tungwah Hospital, Dongguan, China.
Renal failure
|October 31, 2023
概括
血清尿酸与血清肌素比率 (SUA/Scr) 的较高表明,在持续门诊腹腔透析 (CAPD) 患者中,死亡风险增加. 这种生物标志物与更高的全因和心血管死亡率有关.
科学领域:
- 腎臟病學 (nephrology) 是一種神經病學.
- 代谢性疾病研究研究
- 生物标志物发现发现
背景情况:
- 血清尿酸与血清肌素比率 (SUA/Scr) 是一种已知的代谢性疾病的生物标志物.
- 持续门诊腹腔透析 (CAPD) 患者的SUA/Scr与死亡率之间的关联仍未得到研究.
研究的目的:
- 调查SUA/Scr与CAPD患者死亡率之间的关系.
- 评估SUA/Scr作为该人口中所有原因和心血管死亡率的潜在预测因素.
主要方法:
- 一个多中心的回顾性队列研究,涉及中国2480名CAPD患者 (2005-2021年).
- 考克斯的比例危险模型和多变量调整的脊柱回归被用来分析SUA/Scr和死亡率之间的关联.
主要成果:
- 升高的SUA/Scr水平与所有原因和心血管死亡率的增加显著相关.
- 每个单位增加的SUA/Scr与62.9%更高的全因死亡风险和73.0%更高的心血管死亡风险相关.
- 与最低四分位数相比,最高的SUA/Scr四分位数显示所有原因死亡的风险增加了2.36倍,心血管死亡的风险增加了3.70倍.
结论:
- 在CAPD患者中,较高的SUA/Scr水平是所有原因和心血管死亡的重要风险因素.
- SUA/Scr证明了与死亡率的非线性关联,突出了其在CAPD患者风险分层方面的潜在临床实用性.
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