腹膜透析中断的临床风险因素在不同透析持续时间的透析中断
Weizhen Xie1, Li Qin2, Jiaying Huang1
1Department of Nephrology, Molecular Cell Lab for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Ren Ji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Renal failure
|October 31, 2023
概括
长期腹膜透析 (PD) 的成功与年轻,没有糖尿病,良好的营养和较少的炎症有关. 氨酶系统抑制剂 (RASi) 的使用也预测了持续的PD治疗.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 脏替代疗法治疗 脏替代疗法
- 透析是通过透析进行的.
背景情况:
- 腹腔透析 (PD) 是一种关键的置换疗法.
- 患者的坚持和结果与治疗持续时间有很大差异.
- 确定影响PD长期成功的因素对于患者管理至关重要.
研究的目的:
- 调查与腹膜透析停产相关的临床风险因素.
- 分析这些因素在不同治疗时间 (TOT) 的不同时间段.
- 为了确定长期PD维护的预测因素.
主要方法:
- 这是一项追溯的队列研究,在1994年至2011年期间,586名患者开始了PD.
- 患者被跟踪至少10年,直到2021年.
- 基于PD持续时间组的基线特征和结果的分析.
主要成果:
- 长期的PD患者 (>10年) 较年轻,糖尿病较少,营养状况更好 (白蛋白/前白蛋白,nPCR较高),炎症较低 (CRP,WBC),残留功能更好,RASi使用更多.
- 由于超过失败,与腹膜炎相关的死亡和转移到血液透析 (HD) 的风险增加,并且PD持续时间更长.
- 老年,糖尿病,低专蛋白,高白血球,高血压脏病,非RASi使用预测的非移植相关的PD退出.
结论:
- 长期的PD患者表现出有利的基线特征,包括年轻的年龄,没有糖尿病,更好的营养状况和较少的炎症.
- 缺少炎症和使用氨酸-血管新生素系统抑制剂 (RASi) 是持续PD治疗的独立预测因素.
- 这些发现突出了优化长期PD结果的关键因素.
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