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在患有和没有手术前殖民化的患者中,术后黄金葡萄球菌感染
Darren P R Troeman1, Derek Hazard2, Leen Timbermont3
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
手术前的金 Staphylococcus (金 Staphylococcus) (金 Staphylococcus) (金 Staphylococcus) 定居显著增加了手术后发展金 Staphylococcus手术部位感染 (SSIs) 和血液感染 (BSIs) 的风险. 解决可修改和不可修改的因素对于高危患者的预防至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 黄金葡萄球菌手术部位感染 (SSI) 和血液感染 (BSI) 是未达到最佳预防策略的重大术后并发症.
- 需要有关黄金菌SSI和BSI的发病率和病因因素的最新数据,以改善预防.
研究的目的:
- 为了确定手术后的黄金菌SSI和BSI的发生.
- 量化S. aureus感染与患者相关或上下文因素之间的联系.
主要方法:
- 一项多中心队列研究,涉及10个欧洲国家的5004名外科患者.
- 患者在手术前被查S. aureus殖民性,并在手术后被跟踪长达90天.
- 用权重发病率和多变量考克斯比例危险回归模型进行数据分析.
主要成果:
- 黄金菌SSI或BSI的累计加权发病率为载体的2.55%,非载体的0.52%.
- 手术前的金黄色细菌殖民与增加的风险密切相关 (AHR, 4.38).
- 其他相关因素包括不可移除的植入物,乳房切除术,神经外科手术和更高的体重指数.
结论:
- 手术前的黄金菌携带是SSI和BSI发展的重要风险因素.
- 无论是可修改的还是不可修改的因素都会导致金黄色细菌感染的风险.
- 这些发现强调了需要解决已确定的风险因素,以改善预防策略的必要性.
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