激活转录因子4在红细胞发育和thalassemia:一个强大的调节器,具有治疗潜力
Jingmin Li1, Aixiang Lv1, Meihuan Chen1,2
1College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fuzhou, 350001, Fujian Province, People's Republic of China.
Annals of hematology
|October 31, 2023
概括
激活转录因子4 (ATF4) 在红细胞发育中起着关键作用. 了解ATF4如何影响胎儿血红蛋白可能会导致β-血病的新疗法.
科学领域:
- 分子生物学分子生物学
- 血液学 血液学 血液学
- 遗传学 是一个遗传学.
背景情况:
- 激活转录因子4 (ATF4) 是一种转录因子,参与应激反应和细胞代谢.
- ATF4对于红状腺发育至关重要,影响造血干细胞,分化和恒常.
- β-thalassemia是一种遗传性血液疾病,由β-环球蛋白基因突变引起.
研究的目的:
- 调查ATF4在红色球体发育中的作用及其对β-thalassemia的潜在影响.
- 探索ATF4和胎儿血红蛋白 (HbF) 水平之间的复杂关系.
- 确定调节ATF4驱动的β-环球蛋白转录的机制,用于治疗开发.
主要方法:
- 文献综述和对ATF4和红状腺发育现有研究的分析.
- 对调查ATF4与BCL11A和MYB等HbF调节者的相互作用的研究进行审查.
- 分析证据,将ATF4水平与β-环球蛋白的转录调节联系起来.
主要成果:
- ATF4对于红状腺发育的多个阶段至关重要.
- 在调节胎儿血红蛋白 (HbF) 水平方面,ATF4具有复杂的,潜在的双重作用.
- ATF4可能通过与负调节剂 (BCL11A,MYB) 相互作用或直接影响转录来影响HbF.
结论:
- ATF4在红状腺发育中的作用是显著的.
- 需要进一步阐明ATF4影响HbF水平的精确机制.
- 调节ATF4活性为beta-thalassemia提供了一个潜在的治疗途径.
相关概念视频
Transcription Factors
76.0K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
76.0K
General Transcription Factors
5.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.3K
Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Role of Hematopoietic Growth Factors
1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.4K
RNA Polymerase II Accessory Proteins
9.2K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
9.2K
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K


