人类胎盘和对孕前病理变化的进化见解:过去十年的全面审查
Diana Maria Chiorean1, Esra Cobankent Aytekin2, Melinda-Ildiko Mitranovici3
1Department of Pathology, County Clinical Hospital of Targu Mures, Targu Mures, Romania.
Fetal and pediatric pathology
|October 31, 2023
概括
胎盘对于胎儿发育至关重要,但人们对其了解甚少. 本综述详细介绍了胎盘发育,孕前,以及可溶性FMS类氨酸激酶-1 (sFlt-1) 在妊娠障碍中的作用.
科学领域:
- 生殖生物学 生殖生物学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 内分泌学 在内分泌学.
背景情况:
- 胎盘对于胎儿和母亲的健康至关重要,但其复杂性尚未完全理解.
- 诸如子宫前 (PE) 和子宫内胎儿生长限制 (IUGR) 等怀孕疾病是由于胎盘发育受损而产生的.
- 在全球范围内,孕前会影响5-7%的怀孕,由于原因不清楚,会带来重大风险.
研究的目的:
- 审查胎盘在胎儿发育和母亲健康中的作用.
- 阐明孕前的发病原因,重点关注胎盘因素.
- 检查可溶性FMS类氨酸激酶-1 (sFlt-1) 对妊娠并发症和治疗进展的贡献.
主要方法:
- 关于胎盘生物学和孕前的文献综述.
- 分析热囊细胞在胎盘功能中的作用.
- 检查妊娠中涉及sFlt-1,VEGF-A和PlGF的机制.
主要成果:
- 胎盘发育受损是PE和IUGR的基础.
- 主要的PE特征包括异常的螺旋动脉重塑,胎盘缺血症和升高的sFlt-1.
- sFlt-1 抑制 VEGF-A 和 PlGF,影响胎盘功能和母亲的健康.
结论:
- 了解胎盘功能,特别是sFlt-1的作用,对于管理妊娠障碍至关重要.
- sFlt-1是孕前症发病的关键媒介,影响母亲和胎儿的健康.
- 最近针对胎盘功能障碍的治疗策略显示出改善妊娠结果的希望.
更多相关视频
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
854
04:17Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues
Published on: September 8, 2023
1.4K
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Gonadal and Placental Hormones
1.5K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.5K
