癌症缓冲症的新出现的标志物及其与肉类的关系
Melanie Lipshitz1,2, J Visser3, R Anderson4
1Division of Human Nutrition, Stellenbosch University, Stellenbosch, South Africa. melanielevydietician@gmail.com.
Journal of cancer research and clinical oncology
|October 31, 2023
概括
这项研究确定了晚期癌症患者癌症缓解症和肉症的关键生物标志物. 血红蛋白,C反应蛋白 (CRP) 和白蛋白显示出显著的关系,支持它们在临床实践中的使用.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 癌症缓冲症和肉类是影响患者预后的复杂疾病.
- 了解新兴生物标志物对于有效管理至关重要.
- 目前关于特定生物标志物在癌症缓冲症和肉症中的作用的知识有限.
研究的目的:
- 为了研究癌症缓解症的新兴生物标志物.
- 探索这些生物标志物在肉症和预后中的作用.
- 在晚期癌症患者中评估生物标志物,缓冲症和肉症之间的关系.
主要方法:
- 一项前性病例控制研究,涉及40名晚期癌症患者和40名匹配对照.
- 使用骨肌肉指数 (SMI) 通过生物电阻和手握强度 (HGS) 评估的萨尔科佩尼亚.
- 测量的生物标志物包括白蛋白,淋巴细胞和血小板计数,血红蛋白,C反应蛋白 (CRP),细胞因子和H3Cit.
主要成果:
- 癌症患者的SMI和HGS显著降低,其中43%是肉.
- 在白蛋白,血红蛋白,CRP和各种炎症标志物 (例如TNFα,IL-6,IL-8,NLR,PLR,SII) 中观察到显著的差异.
- 专和血红蛋白与肌肉质量有负相关性;与专,血红蛋白和CRP显著相关的萨尔科佩尼亚.
结论:
- 血红蛋白,CRP和白蛋白是重要的生物标志物,支持它们在癌症缓解症评估中的未来使用.
- 对于CXCL5和H3Cit作为癌症缓解症中有价值的生物标志物的作用,需要进一步研究.
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