扩散性曲解成像路径学揭示了阻塞性睡眠呼吸暂停综合征的儿童中白质结构网络的破坏
Yanhua Li1,2, Hongwei Wen3, Wenfeng Li4
1Department of Radiology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 Nanlishilu, Beijing, 100045, China.
Brain imaging and behavior
|October 31, 2023
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的儿童已经破坏了白质 (WM) 大脑网络. 扩散性曲解成像 (DKI) 显示OSA患者的网络效率下降和区域连接性改变,影响认知功能.
科学领域:
- 神经成像是一种神经成像.
- 儿科神经学 儿科神经学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在儿童中很常见.
- OSA可能导致认知缺陷.
- 大脑白质 (WM) 结构网络完整性对认知功能至关重要.
研究的目的:
- 通过扩散曲解成像 (DKI) 来研究OSA儿童的WM结构网络中断.
- 为了将网络变化与OSA的临床特征相关联.
主要方法:
- 利用DKI曲谱学在40名OSA和28名健康儿童中构建个体全脑WM网络.
- 应用图形理论来分析全球和区域网络拓.
- 与OSA临床数据相关联的网络属性.
主要成果:
- 在KFA加权网络中,OSA儿童的全球和本地网络效率下降,KFA加权网络的路径长度增加.
- 在特定的大脑区域观察到节点间中心性 (BC) 的显著变化,包括额叶,岛叶和叶.
- 在默认模式网络区域的改变节点BC与OSA睡眠参数相关.
结论:
- 患有OSA的儿童表现出WM网络的全球整合和本地专业化受损.
- DKI和KFA指标有效地描述了这些WM网络中断.
- 这些发现有助于更好地理解影响认知的OSA病理生理机制.
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