在一般人群中,血清克洛托和腹腔大动脉化之间存在一种新的U形关系
Na Wei1, Zuolei Shi2, Yan Gong3
1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, Shandong, China.
Cardiovascular journal of Africa
|October 31, 2023
概括
在一般人群中,血清溶解α-klotho (SSKL) 与腹腔大动脉化 (AAC) 相反相关. 这种U形关系受到年龄和吸烟状况的影响,这表明klotho对心血管疾病的保护作用.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 腹腔大动脉化 (AAC) 是心血管事件的重要预测因素.
- 克洛托是一种抗衰老蛋白,具有心脏保护性质.
- 在一般人群中,klotho和AAC之间的联系仍然不清楚.
研究的目的:
- 调查血清溶性α-klotho (SSKL) 和AAC之间的关联.
- 探索这种关系的潜在修饰因素,包括年龄和吸烟习惯.
主要方法:
- 从国家健康和营养检查调查中对2,327名参与者的分析.
- 使用多变量逻辑回归和通用添加模型.
- 分层分析根据年龄和吸烟状况对子组进行了检查.
主要成果:
- 在对混因子进行调整后,在lnSSKL和AAC之间观察到负相关性.
- 这种关系呈现出 U 形曲线,其拐点为 7.01 pg/ml.
- 反向关联在男性和吸烟者中持续存在.
结论:
- 在一般人群中,血清溶解α-klotho (SSKL) 与腹腔大动脉化 (AAC) 有负面关联.
- 这种关系是U型的,由年龄和吸烟来调节.
- 这些发现强调了klotho在心血管健康方面的潜在作用.
相关概念视频
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
19
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
19
Skeleton and Calcium Homeostasis
4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Synthesis and Functions of Calcitonin
1.9K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.9K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11
Atherosclerosis I: Introduction
9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9


