孕产妇表达的3基因表达和心率变化在心力衰竭患者与心室心律不整之间的相关性
Ling Lin1, Mei Hou1, Ailing Yang1
1The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Cardiovascular journal of Africa
|October 31, 2023
概括
母体表达的3基因 (MEG3) 水平与心率变化 (HRV) 结合,有效预测心力衰竭患者的腹腔失常. 这种组合为识别心力衰竭并发症风险患者提供了一个有前途的工具.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 生物标志物 生物标志物
背景情况:
- 心力衰竭 (HF) 是一种复杂的疾病,通常由心室心律不整 (VA) 复杂化.
- 确定可靠的VA风险分层的生物标志物在HF患者中对于及时干预至关重要.
- 母体表达的基因3 (MEG3) 是一个长的非编码RNA,在心血管疾病中具有潜在的作用.
研究的目的:
- 在心力衰竭患者中研究血清MEG3表达和心率变化 (HRV) 之间的相关性.
- 评估MEG3和HRV的预测值,单独和组合,对HF患者的VA发生.
主要方法:
- 130名心力衰竭患者的前性研究,分为非VA (n=85) 和VA (n=45) 组.
- 皮尔森相关性分析用于评估血清MEG3,HRV参数和心脏功能指标之间的关系.
- 接收器操作特征 (ROC) 曲线分析,以确定MEG3和HRV对VA发生的预测准确度.
主要成果:
- 与非VA组相比,VA患者的左心脏直径和左心室末端透气直径,左心室下部喷射率和E/A比率显著更高,与非VA组相比.
- 血清MEG3表达与各种HRV参数 (SDANN,SDNN指数,PNN50,RMSSD,LF,HF,VLF) 和心脏功能指标 (LVEF,E/A) 有显著的负相关性.
- 血清MEG3表达与左心脏直径和左心室终端-透缩直径正相关. MEG3和HRV的组合表明,ROC曲线 (0.966) 下的高面积用于预测VA.
结论:
- 血清MEG3表达与心脏功能障碍和心力衰竭患者的改变HRV显著相关.
- MEG3和HRV的组合提供了一个非常有效的预测工具,用于识别患有心力衰竭的患者,这些患者有患心室心律不整的风险.
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