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水凝在眼科中的应用和最新发展

Xi Wang1, FuQiang Li1, Xin Liu1

  • 1Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.

ACS biomaterials science & engineering
|October 31, 2023
PubMed
概括

水凝,高含水量的功能性聚合物网络,在眼科中越来越多地使用. 本综述详细介绍了它们的分类和在眼睛疾病和治疗中的各种应用.

关键词:
生物材料是一种生物材料.药物输送是药物输送的过程.这种水凝是水凝.眼科 眼科 眼科聚合物是一种聚合物.

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...