高的HScore与COVID-19的不良临床结果有关
Rafael Benavente1, Camila Peña2, Allyson Cid3
1Internal Medicine Department, Universidad de Chile, Santiago, Chile.
二次性血细胞淋巴细胞瘤 (sHLH) 在COVID-19患者中不常见. 然而,HScore可以预测住院COVID-19患者的不良结果,如机械通风或死亡率.
科学领域:
- 临界护理医学 临界护理医学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可以引起高炎症,模仿二级血细胞性淋巴细胞瘤 (sHLH).
- 已提出HScore,这是一个用于sHLH的验证工具,用于评估COVID-19相关的炎症.
研究的目的:
- 为了确定住院COVID-19患者中sHLH的发生率.
- 评估HScore作为预后指标的有用性,以预测该群体的不良结果.
主要方法:
- 一项前性研究招募了143名住院COVID-19患者 (21-100岁).
- 在入院后72小时内计算HScore.
- 该研究评估了sHLH发病率和HScore≥130和机械通风或60天死亡率等结果之间的关联.
主要成果:
- 中位数的HScore为96 (范围:33-169).
- 这种SHLH的发病率很低 (0.7%),诊断了一名患者 (HScore 169).
- 一个HScore≥130独立地与一个复合的糟糕的结果 (危险比率2.13,p=0.022) 相关,即使经过对混因子进行调整.
结论:
- 二次性血细胞淋巴细胞瘤 (sHLH) 在COVID-19患者中不常见.
- HScore是预测住院COVID-19患者的不良临床结果的宝贵工具.
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