[先天性甲状腺功能低下症学龄前儿童的认知表现在后续计划中注册]
Esperanza Ontiveros M1, Juan A González M2, Rolando Rivera G1
1Instituto Nacional de Pediatría-UAM-X, Ciudad de México, México.
Andes pediatrica : revista Chilena de pediatria
|October 31, 2023
概括
早期治疗和随访计划显著改善了先天性甲状腺功能低下症 (CH) 儿童的认知结果. 及时干预和一致的监测对于CH患者的最佳神经发育至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经发育儿科 神经发育儿科
- 遗传学 遗传学 是一个
背景情况:
- 先天性甲状腺功能低下症 (CH) 需要及时治疗,以预防神经系统缺陷.
- 早期干预对于限制受影响儿童的长期认知后果至关重要.
- 后续计划可以提高CH儿童的发育结果.
研究的目的:
- 评估诊断为CH的学龄前儿童的认知表现.
- 评估结构化后续计划对CH患者认知发育的影响.
- 确定影响CH儿童认知结果的关键因素.
主要方法:
- 这是一项前性研究,涉及93名被诊断患有心血管疾病的患者.
- 在4,5和6岁时使用韦克斯勒尺度 (WPPSI,WISC-R) 评估认知功能.
- 对全尺度智商 (FSIQ),口头智商 (VIQ) 和性能智商 (PIQ) 成绩的分析.
主要成果:
- 与早期治疗 (24±6天) 相比,晚期开始治疗的儿童 (50±16天) 的智商得分较低.
- 肌和延迟治疗与4岁时的VIQ,PIQ和FSIQ降低相关.
- 在早期接受治疗的儿童与没有定期随访的儿童之间,在6岁时观察到显著的智商分数差异.
结论:
- 早期开始治疗对于CH的认知发展至关重要.
- 将其纳入后续计划和早期刺激会对认知表现产生积极影响.
- 肝炎的病因和治疗时间是认知结果的主要决定因素.
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