生物衰老的节奏 预测 非特异性 慢性 腰痛 严重程度
Edwin N Aroke1, Vinodh Srinivasasainagendra2, Pooja Kottae3
1School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama.
The journal of pain
|October 31, 2023
概括
患有慢性腰部疼痛 (cLBP) 的成年人表现出更快的生物衰老速度,特别是通过DunedinPACE测量. 这种加快的衰老与增加的疼痛严重程度和残疾相关,表明潜在的治疗点.
科学领域:
- 生物遗传学 生物遗传学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 疼痛医学 医学 疼痛医学
背景情况:
- 慢性腰部疼痛 (cLBP) 是一种具有复杂病因的普遍疾病.
- 通过表观遗传钟来评估生物衰老,可以提供对cLBP病理生理学的见解.
- 根据表观基因组测定尼丁衰老速度 (DunedinPACE) 是一种新的衰老速度测量方法.
研究的目的:
- 研究生物衰老速度与非特异性cLBP之间的关联.
- 为了比较不同表观遗传衰老加速措施对cLBP的预测能力.
- 为了确定加速表观遗传衰老是否与cLBP患者的疼痛严重程度和残疾有关.
主要方法:
- 使用了四个表观遗传时钟:DunedinPACE,Horvath,Hannum和PhenoAge. 这是一个很好的方法.
- 在69名患有cLBP的成年人和49名无疼痛对照 (PFC) 中评估了生物衰老速度.
- 采用单变量和多变量回归分析以及相关系数来分析数据.
主要成果:
- 与PFC相比,患有cLBP的参与者表现出明显更高的DunedinPACE分数.
- 与其他时钟不同,DunedinPACE表现出最大的效应大小,是cLBP的强有力的预测指标.
- 较高的DunedinPACE分数与cLBP患者的疼痛严重程度和干扰正相关.
结论:
- 加快表观遗传衰老,特别是通过DunedinPACE测量,与非特异性cLBP相关.
- 尼丁PACE是cLBP比Horvath,Hannum或PhenoAge时钟更强大的预测器.
- 针对减缓生物衰老的干预措施可能是改善cLBP结果的新疗法策略.
关键词:
根据表观基因组的衰老速度 (DunedinPACE)表观遗传年龄加速基因表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表不特定的慢性腰部疼痛 腰部疼痛生物衰老的速度.
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