动态电刺激增强了由皮质脊髓输入的脊髓内部神经元的招募
Giuliano Taccola1, Roger Kissane2, Stanislav Culaclii3
1Neuroscience Department, International School for Advanced Studies (SISSA), Bonomea 265, Trieste, Italy; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Experimental neurology
|October 31, 2023
概括
动态刺激 (DS) 通过增加脊髓内部神经元刺激性来增强皮质脊髓运动反应,即使在脊髓损伤后也是如此. 这种电神经调节在意志输入较弱时会增加运动输出.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 皮层脊髓运动反应可以通过电刺激来促进,即使存在脊髓损伤.
- 了解动态刺激 (DS) 如何影响皮质脊髓输入对于开发有效的神经调节疗法至关重要.
研究的目的:
- 研究DS对脊髓中皮质脊髓输入处理的影响.
- 探索DS期间肌肉招募和皮质唤起的带背部潜力 (CDPs) 之间的关系.
主要方法:
- 开发一种皮质脊柱平台,用于选择性皮质刺激和同时进行DS.
- 获取多站点CDP和电肌图 (EMG) 来评估脊髓活动.
- 使用外围神经刺激验证外围注射器接口.
主要成果:
- DS暂时促进了皮质脊髓运动反应.
- DS可以选择性地增加脊髓内部神经元处理皮质脊髓输入的兴奋性,而不会改变下降的运动命令.
- 在肌肉招募和皮质唤起的CDPs组件之间发现了一种新的相关性.
结论:
- DS增强了后突触脊髓内神经元的兴奋性和反应能力.
- 通过DS进行的电神经调节可以改善因脊髓或大脑功能障碍而导致意志输入受损的情况下的运动输出.
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