雷米马佐拉姆对普罗波福尔在老年患者全身麻醉诱导期间对血液动力学的影响:单中心随机对照试验
Mingfeng He1, Chanjuan Gong1, Yinan Chen1
1Department of Anesthesiology and Perioperative Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Journal of biomedical research
|October 31, 2023
概括
雷米马佐拉姆在老年患者的全身麻醉诱导过程中更好地维持血液动力稳定性,而不是propofol. 这是由于remimazolam的作用.
科学领域:
- 麻醉学 麻醉学
- 心血管生理学心血管生理学
背景情况:
- 一般麻醉的诱导需要仔细的血液动力学监测,特别是在老年患者.
- 普罗波是一种常见的诱导剂,但可以引起显著的低血压.
- 雷米马佐拉姆是一种超短效的二甲,具有潜在的血液动力学优势.
研究的目的:
- 在老年患者的全身麻醉诱导过程中,比较雷米马佐拉姆与普罗波的血液动力学效应.
- 评估这些药物对平均动脉压,心脏指数,中风体积指数和全身血管阻力指数的影响.
主要方法:
- 接受全身麻醉的老年患者被随机分配给接受雷米马佐拉姆或普罗波的诱导.
- 血液动力学参数包括平均动脉压 (MAP),心脏指数 (CI),中风体积指数 (SVI) 和全身血管阻力指数 (SVRI) 在定义的时间点上测量.
- 一个经过处理的脑电图指导了成功的诱导和药物输液停止.
主要成果:
- 在诱导后,雷米马佐拉姆和普罗波都降低了MAP,但在特定时间点 (T2) 服用雷米马佐拉姆时,这种降低不那么明显.
- 雷米马佐拉姆从基线到输管治疗的MAP变化较小 (ΔMAP T0-T2) 和最大MAP降低 (ΔMAP最大).
- 系统性血管阻力指数 (SVRI) 在诱导和输管 (T1-T3) 期间,与普罗波相比,雷米扎洛的系统性血管阻力指数显著更高.
结论:
- 与普罗波相比,雷米马佐拉姆在老年人全身麻醉诱导期间提供了优越的血液动力稳定性.
- 改善的稳定性可能归因于雷米马佐拉姆能够维持更高的全身血管抵抗水平.
- 雷米马佐拉姆代表了在血液动力学上脆弱的老年患者中诱导麻醉的潜在更安全的替代方案.
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