与代谢功能障碍相关的脂肪性肝病和心血管疾病风险
Hyeok-Hee Lee1,2, Han Ah Lee3, Eun-Jin Kim1,2
1Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea.
超过三分之一的成年人患有与代谢功能障碍相关的脂肪性肝病 (MASLD) 或相关疾病,显著增加他们的心血管疾病 (CVD) 风险. 早期识别和管理对于减轻这些风险至关重要.
科学领域:
- 肝病学和胃肠道学
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 与新MASLD定义相关的临床影响和心血管疾病 (CVD) 风险需要进行彻底调查.
- 了解MASLD的流行程度和影响对于公共卫生战略至关重要.
研究的目的:
- 在大量成年人群中确定MASLD和相关疾病的患病率.
- 评估MASLD/相关脂肪性肝病 (SLD) 与心血管事件风险之间的关联.
- 评估不同类别的MASLD和相关肝病的CVD风险.
主要方法:
- 利用了来自9,775,066名年龄在20-79岁之间的成年人的全国健康查数据 (2009).
- 参与者被分为四组:MASLD,MetALD (MASLD与增加的酒精摄入量),MASLD与其他结合病因 (集体MASLD/相关SLD),和没有MASLD/相关SLD.
- 随访了8,808,494名没有先前心血管疾病的参与者,平均为12.3年,以确定心血管疾病事件 (心肌梗塞,缺血性中风,心力衰竭,心血管死亡).
主要成果:
- MASLD,MetALD和MASLD与其他联合病因的患病率分别为27.5%,4.4%和1.5%.
- 在随访期间,共发生了272,863起心血管疾病事件.
- 患有MASLD/相关SLD的参与者表现出显著更高的心血管疾病事件风险 (调整HR 1.38;95%CI 1.37-1.39),MASLD (HR 1.39),MetALD (HR 1.28) 和MASLD与其他联合病因 (HR 1.30) 的特定风险.
结论:
- 据估计,超过三分之一的韩国成年人患有MASLD或相关的脂肪性肝病.
- 患有MASLD/相关SLD的个人面临心血管疾病的风险大幅增加.
- 这些发现强调了积极查和管理MASLD的必要性,以减少心血管疾病发病率和死亡率.
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