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Updated: Jul 12, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Published on: June 9, 2017

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一个F-qNMR引导的数学模型,用于G蛋白合受体信号传递

Jesús Giraldo1, Jesper J Madsen2, Xudong Wang2

  • 1Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona (J.G.), Bellaterra, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (J.G.), CIBERSAM, Spain; Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona (J.G.), Spain; Global and Planetary Health, College of Public Health (J.J.M.), Center for Global Health and Infectious Diseases Research, College of Public Health (J.J.M.), Department of Molecular Medicine, Morsani College of Medicine (J.J.M.), Department of Molecular Biosciences (X.W., L.Y.), University of South Florida, Tampa, Florida; Department of Pharmacology and Chemical Biology, University of PittsburghSchool of Medicine (L.W., C.Z.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Lee Moffitt Cancer Center & Research Institute, Tampa, Florida (L.Y.) Jesus.Giraldo@uab.es libinye@usf.edu.

Molecular pharmacology
|October 31, 2023
PubMed
概括

这项研究引入了一种新的G蛋白合受体 (GPCR) 信号效能的数学模型,超越了简单的ON/OFF开关. 它量化了多个受体状态,以更好地了解连接体反应,并开发更准确的信号模型.

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