20个代表性的猪嗅觉受体基因的个体和种群多样性
Mingue Kang1, Byeongyong Ahn1, Seungyeon Youk1
1Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
Scientific reports
|November 1, 2023
概括
猪嗅觉受体 (OR) 基因中的遗传变异会影响诸如行为和繁殖等特征. 这项研究揭示了哺乳动物中常见的OR基因特征,包括拷贝数变异和猪的品种特异性等位基因.
科学领域:
- 动物遗传学 动物遗传学
- 嗅觉受体基因进化过程
- 哺乳动物基因组学
背景情况:
- 嗅觉受体 (OR) 基因显著影响动物表型,包括行为,繁殖和养.
- 在许多物种中,OR亚基因组及其变异的复杂性仍然不太清楚.
- 描述OR基因对于理解动物生物学中嗅觉影响的特征至关重要.
研究的目的:
- 在七种猪品种中,对20个代表性嗅觉受体 (OR) 基因内的遗传变异进行了表征.
- 研究牲畜中OR基因的种群水平多样性和进化特征.
- 在猪OR亚基因组中识别品种特定的等位基因和潜在的功能丧失等位基因.
主要方法:
- 基于序列的OR类型方法应用于7个猪品种56个个体的1120个样本.
- 分析了来自13个OR家族的20个代表性OR基因,这些基因位于14个猪染色体上.
- 猪和狗OR基因之间的核酸序列多样性的比较分析.
主要成果:
- 确定了猪中常见的哺乳动物OR基因特征,包括拷贝数变异和保存的位置特异性多样性.
- 在猪OR基因中检测到大量的品种特异性等位基因和功能丧失等位基因的存在.
- 与狗相比,在猪OR基因中观察到更高的核酸序列多样性,这表明不同的进化压力.
结论:
- 猪OR基因表现出哺乳动物共同的特征,例如拷贝数变异和净化选择.
- 与狗相比,猪OR中的高核酸多样性凸显了特定物种的进化轨迹.
- 这项研究首次全面描述了许多OR家族基因在牲畜中的个体和种群水平,为嗅觉受体基因进化提供了洞察力.
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