诊断时间1年后,ADHD患者的功能结果在中心之间存在差异
Massimo Cartabia1, Stefano Finazzi2, Maurizio Bonati3
1Laboratory of Pharmacoepidemiology, Department of Public Health, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Scientific reports
|November 1, 2023
概括
这项研究发现,在不同中心的ADHD治疗结果中存在显著的差异. 结合疗法显示出更好的结果,突出了提高患者护理的标准化方法的需要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床研究 临床研究
背景情况:
- 对注意力缺陷/多动障碍 (ADHD) 的药理疗法已经得到了充分的研究.
- 关于不同治疗方法及其在不同治疗中心的结果的有限比较数据存在.
研究的目的:
- 评估ADHD患者诊断后一年功能结果的变化.
- 分析接受治疗如何影响不同中心的治疗结果.
主要方法:
- 多中心观察性研究,使用来自16个ADHD中心的1429名患者的数据 (2011-2022年).
- 用于评估治疗有效性的通用线性混合模型,考虑到患者和中心的特征.
- 倾向性得分权重用于调整所接受的治疗.
主要成果:
- 与单独的甲基化物 (54.4%),单独的心理治疗 (53.4%) 或没有治疗 (40.5%) 相比,联合ADHD治疗的改善率显著更高 (65.5%).
- 观察到患者功能改善的中心间显著差异,调整后预期改善率在47.7%至61.2%之间.
- 中心特定的治疗方法似乎在很大程度上解释了观察到的结果差异.
结论:
- 在治疗中心之间,多动症患者的治疗结果存在很大差异.
- 建议采用标准化治疗策略和定期审计,以减少结果差异并提高护理的一致性.
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