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Updated: Jul 12, 2025

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
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Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

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诺基诺和β-乳糖抗菌剂诱导Salmonella enterica持久细胞中的不同的转录组概况

S P Mattiello1,2,3,4, V C Barth5, J Scaria4,6

  • 1Laboratório de Imunologia e Microbiologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Av. Ipiranga, 6681, Porto Alegre, 90619-900, Brazil.

Scientific reports
|November 1, 2023
PubMed
概括

沙门氏菌持久细胞在用西普洛素或塞夫塔齐迪姆治疗时表现出明显的基因表达模式. 这项研究揭示了对不同抗生素压力的独特的转录基因反应,影响了持续形成.

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Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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