孕前母亲血压与早产的关联:基于人口的队列研究
Wenxue Xiong1, Lu Han2, Xijia Tang1
1Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
孕前怀孕 血压升高 (BP) 和高血压显著增加了早产 (PTB) 的风险. 监测和管理预设BP对于预防PTB至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 孕前血压 (BP) 和早产 (PTB) 之间的关系需要进一步澄清.
- 孕前血压水平是对母亲和胎儿健康结果的关键指标.
- 了解这些关联可以为公共卫生战略和临床干预提供信息.
研究的目的:
- 调查母亲预孕BP与PTB风险之间的关联.
- 检查预先概念BP类别和PTB之间的剂量反应关系.
- 确定影响BP-PTB关联的潜在修改因素.
主要方法:
- 在715,984名接受孕前健康检查的中国妇女中进行了基于人口的队列研究.
- 接受过培训的卫生工作者测量的孕产妇预孕BP;PTB作为主要结果.
- 多变量逻辑回归和受限立方线回归用于分析关联和剂量反应关系.
主要成果:
- 孕前高血压与PTB的风险增加1.24倍有关 (aOR:1.24;95%CI:1.14-1.34).
- 高血压,第一阶段和第二阶段的高血压显示PTB风险显著增加 (aOR分别为1.09,1.24,1.43).
- 观察到分别在怀孕前的缩和腹缩血压和PTB风险之间存在U形和线性剂量反应关系.
结论:
- 孕产妇预先怀孕高血压和高血压是PTB的显著,可修改的风险因素.
- 这些发现支持2017年ACC/AHABP标准,用于识别高风险怀孕.
- 这些结果为有针对性的公共卫生和临床干预提供了证据,以减少PTB.
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