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在癌症患者中使用稳定同位素进行代谢途径分析

Caroline R Bartman¹, Brandon Faubert², Joshua D Rabinowitz³

¹Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

Nature reviews. Cancer

|November 1, 2023

概括

稳定同位素追踪揭示了人类瘤如何利用各种营养物质进行生长. 这种方法有助于了解癌症代谢及其与不良临床结果的联系,为癌症研究提供了新的途径.

科学领域:

在瘤学瘤学.
代谢途径代谢途径
癌症生物学癌症生物学

背景情况:

代谢重编程对于癌症的发展和生长至关重要.
瘤的新陈代谢受到复杂的内在和外在因素的影响.
在体内评估癌症代谢,特别是在患者中,是非常有价值的.

研究的目的:

审查使用in vivo稳定同位素追踪研究瘤代谢的方法.
定义瘤燃料偏好和代谢途径参与.
突出这一领域的新兴原则和挑战.

主要方法:

使用稳定同位素追踪技术.
在体内给予稳定同位素输注.
分析瘤中的代谢途径,包括三酸循环和氨基酸合成.

主要成果:

人类瘤在中央代谢途径中表现出多样化的营养利用.
在体内稳定同位素追踪提供了关于瘤燃料偏好的见解.
某些代谢活动与不良的临床结果和癌症进展相关.

结论:

在体内稳定同位素追踪是剖析瘤代谢的强大工具.
了解瘤代谢重编程可以确定新的治疗点.
需要进一步的研究来克服挑战,并推进癌症代谢的发现.

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