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Updated: Jul 12, 2025

Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis
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IRE1α通过调节依赖progranulin的XBP1拼接和原平衡来预防骨关节炎

Li Liang1, Fengmei Zhang1,2, Naibo Feng1

  • 1Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China.

Experimental & molecular medicine
|November 1, 2023
PubMed
概括

需要内醇的酶1α/X盒结合蛋白-1拼接 (IRE1α/XBP1s) 途径对于在骨关节炎 (OA) 中保持软骨稳定性至关重要. 它的缺乏加速了OA的进展,突出了IRE1α/ERN1作为关节疾病的潜在治疗点.

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