通过利用血管和免疫调节来实现瘤微环境的正常化,以实现增强的癌症治疗
Yechan Choi1, Keehoon Jung2,3,4
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Experimental & molecular medicine
|November 1, 2023
概括
瘤微环境的正常化,专注于血管和免疫系统,提供了一个有前途的战略. 向疗法可以通过使瘤血管和免疫细胞正常化来改善结果,从而提高癌症治疗的疗效.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 固体瘤通过血管生成和免疫抑制创造了一个支持性的微环境.
- 抗血管性药物在削弱瘤血管系统方面表现出有限的有效性.
- 调节瘤微环境对于有效的癌症治疗至关重要.
研究的目的:
- 审查瘤微环境中的血管和免疫正常化概念.
- 讨论实现血管和免疫正常化的策略.
- 突出癌症治疗中正常化方法的潜力.
主要方法:
- 对瘤微环境正常化现有文献的综述.
- 针对血管正常化的策略的分析.
- 针对免疫正常化的策略的分析.
主要成果:
- 血管正常化,而不是血管修剪,当与其他疗法相结合时,可以改善结果.
- 免疫正常化包括抑制免疫抑制细胞和激活免疫刺激细胞.
- 正常化策略在抑制瘤生长和改善生存率方面表现有前途.
结论:
- 血管和免疫正常化是克服瘤诱导的免疫抑制和异常血管结构的关键策略.
- 有针对性的正常化方法可以提高现有的抗癌疗法的疗效.
- 对正常化策略的进一步研究具有改善癌症患者治疗结果的巨大潜力.
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