感知脂肪组织中的氧气和温度 - - 谁感知什么?
Gi-Sue Kang1, Hye-Ju Jo1, Ye-Rim Lee1
1College of Veterinary Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea.
Experimental & molecular medicine
|November 1, 2023
概括
白色脂肪组织中的缺氧诱导因子 (HIF) 信号驱动在肥胖期间的炎症和胰岛素抵抗. 组织特定的淘汰赛小鼠显示HIF.
科学领域:
- 脂肪组织生物学 脂肪组织生物学
- 代谢性疾病研究研究.
- 细胞适应机制的细胞适应机制
背景情况:
- 脂肪组织是复杂的器官,应对环境变化,如饮食引起的肥胖.
- 低氧诱导因子 (HIF) 在肥胖期间在白色脂肪组织中被激活,影响新陈代谢,血管生成和细胞存活.
- 棕色脂肪组织通过UCP1产生热量,这一过程可以在白色脂肪组织 ("棕色化") 中模拟.
研究的目的:
- 审查组织特异性淘汰赛小鼠研究HIF在饮食诱导肥胖中的作用的研究结果.
- 在脂肪组织巨细胞,脂肪细胞和内皮细胞中剖析HIF通路的细胞特异性功能.
- 了解HIF信号如何促进肥胖症的炎症和胰岛素抵抗.
主要方法:
- 用转基因小鼠进行组织特异性淘汰 (KO) 用于HIF通路.
- 分析Ucp1 KO小鼠和针对特定脂肪细胞类型的HIF模型的数据.
- 审查那些解读HIF在饮食诱导肥胖模型中的作用的研究.
主要成果:
- 脂肪细胞和脂肪组织巨细胞中完整的HIF-1信号会加剧炎症和胰岛素抵抗.
- 使用KO小鼠的研究强调了HIF在脂肪组织内的特定细胞类型中的关键作用.
- 调查HIF,UCP1和肥胖细胞反应之间的相互作用.
结论:
- 特定脂肪组织细胞类型中的HIF信号在与肥胖相关的炎症和胰岛素抵抗中起着至关重要的作用.
- 组织特异性KO模型是理解代谢疾病中复杂细胞机制的重要工具.
- 针对不同脂肪细胞种群中的HIF通路可能为肥胖提供治疗策略.
相关概念视频
01:14Temperature Measurement Sites
1.7K
A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
1.7K
01:43Thermosensation
30.5K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.5K