卵巢储备的减少导致了不良的ART结果,这些结果归因于对累积细胞中氧代谢功能的影响
Cong Zhang1,2,3,4,5,6,7, Shi Song1,2,4,5,6, Ming Yang1,2,4,5,6
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
BMC genomics
|November 1, 2023
概括
卵巢储备减少 (DOR),而不是晚年,显著影响辅助生殖治疗 (ART) 的结果. 与DOR相关的累积细胞 (CCs) 的氧化代谢变化可能会损害卵细胞质量,强调评估卵巢储备的重要性.
科学领域:
- 生殖医学 生殖医学
- 细胞生物学 细胞生物学
- 基因组学就是基因组学.
背景情况:
- 老年妇女的卵细胞质量下降是成功辅助生殖治疗 (ART) 的障碍.
- 卵巢储备减少 (DOR) 经常伴随着衰老,并影响卵细胞质量.
- 累积细胞 (CCs) 反映了卵细胞的质量,对卵细胞的发育和成熟至关重要.
研究的目的:
- 调查老年妇女卵细胞质量下降的根本原因.
- 确定累积细胞 (CCs) 在与年龄相关的卵细胞质量下降中的作用.
- 为了区分时间年龄与卵巢储备状态对ART结果的影响.
主要方法:
- 根据年龄和卵巢储备状态,从四个组收集了99个累积细胞 (CC) 样本.
- 分析了临床ART结果.
- 在CCs上进行了转录表达概况,以确定分子差异.
主要成果:
- 卵巢储备 (DOR) 的减少,无论年龄如何,都与不良ART结果有显著的联系.
- 在正常卵巢储备 (NOR) 的年轻女性和NOR的老年女性之间没有观察到ART结果的显著差异.
- DOR诱导了CC的转录变异,特别是在与氧化代谢相关的途径中.
结论:
- 老年患者的ART结果主要归因于卵巢储量减少 (DOR),而不是年龄本身.
- 改变CC中的氧代谢可能会破坏它们对卵细胞的支持功能.
- 卵巢储备状况是ART成功的更重要的预测因素,而不是年龄,因此需要及时评估,即使在老年妇女中出现轻微的临床症状.
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