静脉血栓栓塞的风险评估在住院的癌症患者:一个单一的中心研究
Supratik Rayamajhi1,2, Shiva Shrotriya1,2,3, Manoj Rai1,4
1Department of Internal Medicine, Michigan State University, East Lansing, MI, USA.
概括
低血红蛋白或脏疾病的住院癌症患者面临更高的静脉血栓栓塞 (VTE) 风险. 一种新的风险评估模型 (RAM) 对识别不太可能患有VTE的患者显示出希望.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 静脉血栓塞栓症 (VTE) 是住院癌症患者的一种严重并发症.
- 识别高风险的患者VTE对于有效的预防和管理至关重要.
- 现有的风险评估模型 (RAM) 可能需要针对这一特定人群进行改进.
研究的目的:
- 在住院癌症患者中确定VTE的关键预测因子.
- 利用人口,临床和实验室数据开发和评估一种新的VTE风险评估模型 (RAM).
- 评估该模型在预测该队列内的VTE风险方面的表现.
主要方法:
- 对住院癌症患者的人口,临床和实验室数据的回顾性分析.
- 为VTE开发一个多变量预测模型.
- 评估模型的区分性表现,灵敏度,特异性和预测值.
主要成果:
- 被归类为非常高或高风险的患者,低血红蛋白水平的患者和患有脏疾病的患者表现出明显增加的VTE风险.
- 开发的VTE RAM表现出中度的歧视性性能,高特异性和高负预测值.
- 该模型的积极预测值和灵敏度受到研究人群中静脉瘤发病率较低的限制.
结论:
- 低血红蛋白和脏疾病是住院癌症患者静脉动脉突发症的重要预测因素.
- 开发的VTE RAM显示了在大多数患者中有效排除VTE风险的潜力.
- 需要进一步验证和改进,以提高模型的灵敏度和更广泛的临床应用的积极预测价值.
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